Pyridyl derivatives and their use as therapeutic agents

aaaa Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is -O-, -N(R1)-, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O...

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Main Authors Abreo, Melwyn, Harvey, Daniel F, Gschwend, Heinz W, Li, Wenbao, Tu, Chi, Kamboj, Rajender, Winther, Michael D, Kodumuru, Vishnumurthy, Hudson, Cindy J, Kondratenko, Mikhail A, Liu, Shifeng, Raina, Vandna, Sviridov, Serguei, Zhang, Zaihui, Bagherzadeh, Mehran Seid, Sun, Shaoyi
Format Patent
LanguageEnglish
Published 20.10.2009
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Summary:aaaa Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is -O-, -N(R1)-, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)-, C(O)O-, S(O)2-, S(O)2N(R1)- or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R9, R9, R10 and R10are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.