Method for enantioselectively opening oxetan-2-ones

Candida antartica Burkholderia plantarii 123 1101 2 A method for preparing substantially enantiopure 3-hydroxy carboxylic acids or esters of the general formula (III) by reacting racemic oxetan-2-ones of the general formula (I) with compounds R3-OH of the general formula (II) in the presence of a li...

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Bibliographic Details
Main Authors Habicher, Tilo, Stürmer, Rainer
Format Patent
LanguageEnglish
Published 01.09.2009
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Summary:Candida antartica Burkholderia plantarii 123 1101 2 A method for preparing substantially enantiopure 3-hydroxy carboxylic acids or esters of the general formula (III) by reacting racemic oxetan-2-ones of the general formula (I) with compounds R3-OH of the general formula (II) in the presence of a lipase from or , and separating the resulting products of the formula (III) and (IV) from one another where the radicals have the following meaning: R, R, Rindependently of one another H; C-C-substituted or unsubstituted alkyl, substituted or unsubstituted aryl or hetaryl, where Rand Rmay not simultaneously have the same meaning.