Nanoparticle composite-coated glass microspheres for use in bioassays

A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivi...

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Bibliographic Details
Main Authors Croker, Kevin Michael, Damore, Michael B, Kourtakis, Kostantinos, Perry, Michael P, Prober, James M, Stull, Paul Douglas
Format Patent
LanguageEnglish
Published 11.08.2009
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Summary:A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.