Alternative oxidase and uses thereof

Drosophila The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in has been shown to conf...

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Bibliographic Details
Main Authors Frederic Rustin, Pierre Jean, Jacobs, Howard T, Dassa, Emmanuel Philippe, Hakkaart, Gerrit A J, Fernandez-Ayala, Daniel Jose Moreno
Format Patent
LanguageEnglish
Published 11.08.2009
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Summary:Drosophila The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in has been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.