Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof

The present invention is directed to phenylalanine ammonia lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologica...

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Bibliographic Details
Main Authors Vellard, Michel Claude, Fitzpatrick, Paul Andrew, Kakkis, Emil D
Format Patent
LanguageEnglish
Published 12.05.2009
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Summary:The present invention is directed to phenylalanine ammonia lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.