Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors

• Main Authors: Allen, David George, Coe, Diane Mary, Cook, Caroline Mary, Cooper, Anthony William James, Dowle, Michael Dennis, Edlin, Christopher David, Hamblin, Julie Nicole, Johnson, Martin Redpath, Jones, Paul Spencer, Lindvall, Mika Kristian, Mitchell, Charlotte Jane, Redgrave, Alison Judith
• Format: Patent
• Language: English
• Published: 05.05.2009

1 1-41-3222 13a 1-33 3-63-85-71 2 24The invention relates to a compound of formula (I) or a salt thereof: wherein: Ris Calkyl, Cfluoroalkyl or -(CH)OH; Ris a hydrogen atom (H), methyl or Cfluoroalkyl; Ris a hydrogen atom (H) or Calkyl; Ris optionally substituted branched Calkyl, optionally substituted Ccycloalkyl, optionally substituted mono-unsaturated-Ccycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which nand nindependently are 1 or 2; and Y is O, S, SO, or NR; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.