Antibodies for preventing and treating attaching and effacing

Escherichia coli The present invention relates to antibodies immunologically specific for an attaching and effacing (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is im...

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Bibliographic Details
Main Authors Fairbrother, John M, Harel, Josée, Batisson, Isabelle, Girard, Francis, Guimond, Marie-Pierre
Format Patent
LanguageEnglish
Published 04.11.2008
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Summary:Escherichia coli The present invention relates to antibodies immunologically specific for an attaching and effacing (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is immunologically specific for an AEEC virulence-associated protein and is capable of preventing an in vivo AEEC intestinal infection when administered to a mammal. The antibody of the invention is preferably useful for preventing the development of A/E intestinal lesions associated with the AEEC. This is achieved by preferably using IgY antibodies immunologically specific for one or more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.