Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction

1 5 2346789 10 3232323211 32222 The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyper...

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Main Authors Gericke, Rolf, Beier, Norbert, Poeschke, Oliver, Burgdorf, Lars, Drosdat, Helga, Lang, Florian
Format Patent
LanguageEnglish
Published 29.07.2008
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Abstract 1 5 2346789 10 3232323211 32222 The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: Rand Rindependently of one another represent H, OH, OA, OAc or methyl; R, R, R, R, R, R, Rand Rindependently of one another represent H, OH, OA, OAc, OCF, Hal, NO, CF, A, CN, OSOCH, SOCH, NH, or COOH; Rrepresents H or CH; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH, CHCH, OCHor -CH(OH)- and Hal represents F, Cl, Br or I.
AbstractList 1 5 2346789 10 3232323211 32222 The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: Rand Rindependently of one another represent H, OH, OA, OAc or methyl; R, R, R, R, R, R, Rand Rindependently of one another represent H, OH, OA, OAc, OCF, Hal, NO, CF, A, CN, OSOCH, SOCH, NH, or COOH; Rrepresents H or CH; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH, CHCH, OCHor -CH(OH)- and Hal represents F, Cl, Br or I.
Author Beier, Norbert
Poeschke, Oliver
Burgdorf, Lars
Lang, Florian
Gericke, Rolf
Drosdat, Helga
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References (WO 01/70213) 20010900
(11-106371) 19990400
Issa et al., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 31(1), 95-105, 2001.
XP-002316520; Beilstein Registry #3365109; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1.
(101 49 393) 20030400
(WO 02/17893) 20020300
XP-001205216 ; Pandeya et al. ; "Design of semicarbazones and their bio-isosteric analogues as potential anticonvulsants"; Pharmazie vol. 56, 2001; pp. 121-125.
Lang et al. (2004/0038882) 20040200
(WO 02/074987) 20020900
Markham et al. (2003/0225126) 20031200
Muanprasat et al., Journal of General Physiology, 124(2), 125-137, Aug. 2004.
XP-002316516; STN CA Caesar accession No. 1142; pp. 1-2.
Pandeya et al., Pharmazie, 56(2), 121-124, 2001.
Dilanyan et al., Chemical Abstracts, 125:212091, 1996.
XP-002316514; 1/6-(c) File Chemcats; accession No. 2001:2460460; pp. 1-4.
XP-002316518; STN CA Caesar accession No. 1135; pp. 1.
(WO 02/070464) 20020900
(0 889 127) 19990100
XP-002316519; STN CA Caesar accession No. 1165; pp. 1.
XP-002316513; Chemcats-ChemStar Product List; Apr. 2003: pp.1-4; accession No. 2000:911593.
XP-002316517; STN CA Caesar accession No. 1163; pp. 1.
Pandeya et al., Acta Pharmaceutica (Zagreb, Croatia), 53(1), 15-24, 2003.
XP-002316515; STN CA Caesar accession No. 1167; pp. 1-2.
Kotali et al., Chemical Abstracts, 125:275360, 1996.
(WO-01/70213) 20010900
(WO 00/62781) 20001000
(0 294 258) 19881200
Burri et al. (2004/0110963) 20040600
XP-002316521; Beilstein Registry #2381518; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1.
XP-002316522; Beilstein Registry #3324432; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1-2.
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