Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction

1 5 2346789 10 3232323211 32222 The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyper...

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Main Authors Gericke, Rolf, Beier, Norbert, Poeschke, Oliver, Burgdorf, Lars, Drosdat, Helga, Lang, Florian
Format Patent
LanguageEnglish
Published 29.07.2008
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Summary:1 5 2346789 10 3232323211 32222 The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: Rand Rindependently of one another represent H, OH, OA, OAc or methyl; R, R, R, R, R, R, Rand Rindependently of one another represent H, OH, OA, OAc, OCF, Hal, NO, CF, A, CN, OSOCH, SOCH, NH, or COOH; Rrepresents H or CH; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH, CHCH, OCHor -CH(OH)- and Hal represents F, Cl, Br or I.