Tetrahydrofuran derivatives having cis substituent, their intermediates, and their preparation method

2 5 23 5 23 5 The present invention relates to a tetrahydrofuran compound having cis substituents, the derivatives thereof and a process for preparing the same, and in particular relates to a dihydrofuran-3-ylidene triflate compound having cis substituents at Cand Cpositions prepared through Prins-t...

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Main Authors Cho, Yong Seo, Choo, Hyunah, Cha, Joo Hwan, Pae, Ae Nim, Chavre, Satish N, Choi, Kyung Il
Format Patent
LanguageEnglish
Published 17.06.2008
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Summary:2 5 23 5 23 5 The present invention relates to a tetrahydrofuran compound having cis substituents, the derivatives thereof and a process for preparing the same, and in particular relates to a dihydrofuran-3-ylidene triflate compound having cis substituents at Cand Cpositions prepared through Prins-type cyclization using a homopropargylic alcohol derivative as a starting material in the presence of Lewis acid catalyst, a tetrahydrofuran compound having cis substituents at C, Cand Cpositions prepared through the hydrolysis of triflate group in the derivatives of the dihydrofuran-3-ylidene triflate compound, and a preparation method thereof.The derivatives and the target tetrahydrofuran compound prepared according to the present invention are hydrofuran compounds with novel structures having cis substituents at C, Cand/or Cpositions, which are useful as a derivative for synthesizing drugs such as an antagonist for neurokinin receptor.