Methods and materials for optimization of electronic transportation and hybridization reactions

Methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device. The low conductivity buffer may also contain a zwitterion. A current and voltage is applied to a location of the device to effect electroph...

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Main Authors Smolko, Daniel D, Swanson, Paul D, Hodko, Dalibor, Canter, David, Haigis, Robert W, Patterson, Tricia
Format Patent
LanguageEnglish
Published 01.01.2008
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Abstract Methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device. The low conductivity buffer may also contain a zwitterion. A current and voltage is applied to a location of the device to effect electrophoretic transportation of the nucleic acid towards the location. The nucleic acid is then hybridized to a nucleic probed located at the location. The reducing agent in the low conductivity buffer may also be acting as a chaotropic agent.
AbstractList Methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device. The low conductivity buffer may also contain a zwitterion. A current and voltage is applied to a location of the device to effect electrophoretic transportation of the nucleic acid towards the location. The nucleic acid is then hybridized to a nucleic probed located at the location. The reducing agent in the low conductivity buffer may also be acting as a chaotropic agent.
Author Patterson, Tricia
Smolko, Daniel D
Canter, David
Hodko, Dalibor
Haigis, Robert W
Swanson, Paul D
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  givenname: Paul D
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  givenname: Dalibor
  surname: Hodko
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  surname: Canter
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  givenname: Robert W
  surname: Haigis
  fullname: Haigis, Robert W
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  givenname: Tricia
  surname: Patterson
  fullname: Patterson, Tricia
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