Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5

1234511 Novel triazole compounds represented by Formula (1): (where A, A, A, A, A, A, B, R, W, X, Y and Z are as defined herein) in which the triazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) anoth...

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Main Authors Cosford, Nicholas D. P, Roppe, Jeffrey R, Tehrani, Lida R, Wang, Bowei
Format Patent
LanguageEnglish
Published 11.09.2007
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Summary:1234511 Novel triazole compounds represented by Formula (1): (where A, A, A, A, A, A, B, R, W, X, Y and Z are as defined herein) in which the triazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases