Degradable polyacetal polymers

Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily...

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Bibliographic Details
Main Authors Brocchini, Stephen J, Heller, Jorge, Tomlinson, Ryan, Duncan, Ruth, Garrett, Shane, Klee, Marcus M
Format Patent
LanguageEnglish
Published 22.05.2007
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Summary:Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily in low pH conditions. Conjugates of the polymers with drugs, especially anticancer drugs, and methods of treatment of cancer.