Helical nucleopeptides
Bnm The present invention relates to peptide-based nucleic acid surrogates (PNAs) having a repeating structure of (AA-aa)and a particular secondary structure that can bind to particular single-stranded nucleic acid targets. Preferably the peptide-based nucleic acid surrogate has an alpha-helical sec...
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| Main Author | |
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| Format | Patent |
| Language | English |
| Published |
27.02.2007
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| Online Access | Get full text |
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| Summary: | Bnm The present invention relates to peptide-based nucleic acid surrogates (PNAs) having a repeating structure of (AA-aa)and a particular secondary structure that can bind to particular single-stranded nucleic acid targets. Preferably the peptide-based nucleic acid surrogate has an alpha-helical secondary structure (αPNA). Also, the present invention relates to the method of forming peptide-based nucleic acid surrogates having a particular secondary structure. The nucleic acid surrogates may be utilized for therapeutic (antisense, antigene), diagnostic (genetic), and molecular switching (αPNA chips) applications. |
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