Process for preparing a pharmaceutically active compound and for preparing its intermediate

The invention discloses a method for preparing the intermediate 2-(2,3-dichlorophenyl)-2-(aminoguanidine)acetonitrile of formula (II), which comprises the reaction of 2,3-dichlorobenzoyl cyanide with aminoguanidine bicarbonate in non-aqueous medium in the presence of methanesulphonic acid, which pro...

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Bibliographic Details
Main Authors Bessa Bellmunt, Jordi, Dalmases Barjoan, Pere
Format Patent
LanguageEnglish
Published 20.02.2007
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Summary:The invention discloses a method for preparing the intermediate 2-(2,3-dichlorophenyl)-2-(aminoguanidine)acetonitrile of formula (II), which comprises the reaction of 2,3-dichlorobenzoyl cyanide with aminoguanidine bicarbonate in non-aqueous medium in the presence of methanesulphonic acid, which produces good yields and short reaction times.Said intermediate is useful for preparing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of formula (I). The invention also relates to a method for preparing (I) with high purity