Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade

• Main Authors: South, Michael S, Parlow, John J, Jones, Darin E, Case, Brenda, Dice, Tom, Lindmark, Richard, Hayes, Michael J, Rueppel, Melvin L, Fenton, Rick, Franklin, Gary W, Huang, Horng-Chih, Huang, Wei, Kusturin, Carrie, Long, Scott A, Neumann, William L, Reitz, David B, Trujillo, John I, Wang, Ching-Cheng, Wood, Rhonda, Zeng, Qingping, Mahoney, Matthew W
• Format: Patent
• Language: English
• Published: 10.10.2006

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...