Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...

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Main Authors South, Michael S, Parlow, John J, Jones, Darin E, Case, Brenda, Dice, Tom, Lindmark, Richard, Hayes, Michael J, Rueppel, Melvin L, Fenton, Rick, Franklin, Gary W, Huang, Horng-Chih, Huang, Wei, Kusturin, Carrie, Long, Scott A, Neumann, William L, Reitz, David B, Trujillo, John I, Wang, Ching-Cheng, Wood, Rhonda, Zeng, Qingping, Mahoney, Matthew W
Format Patent
LanguageEnglish
Published 10.10.2006
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Summary:The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.