Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors

A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceuticall...

Full description

Saved in:
Bibliographic Details
Main Authors Gardelli, Cristina, Giuliano, Claudio, Harper, Steven, Koch, Uwe, Narjes, Frank, Ontoria Ontoria, Jesus Maria, Poma, Marco, Ponzi, Simona, Stansfield, Ian, Summa, Vincenzo
Format Patent
LanguageEnglish
Published 15.08.2006
Online AccessGet full text

Cover

More Information
Summary:A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme