Immunomodulatory compounds

The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes,...

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Main Authors Matthews, Ian Richard, Coulter, Thomas Stephen, Ghiron, Chiara, Brennan, Chris James, Uddin, Muhammed Kamal, Pettersson, Lars Olof Göran, da Graca Thrige, Dorthe, Huxley, Philip
Format Patent
LanguageEnglish
Published 25.07.2006
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Summary:The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.