Preparation and purification of antiviral disulfonic acid disodium salt

The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.

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Bibliographic Details
Main Authors Iera, Silvio, Demerson, Christopher A, Lunetta, Jacqueline F, Papamichelakis, Maria, MacEwan, Michael F, McMahon, Wayne G, Potoski, John R, Mohan, Arthur G, Nikitenko, Antonia
Format Patent
LanguageEnglish
Published 01.11.2005
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Summary:The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.