Antipicornaviral compounds, their preparation and use

Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful...

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Bibliographic Details
Main Authors Dragovich, Peter Scott, Webber, Stephen Evan, Prins, Thomas Jay, Zhou, Ru, Marakovits, Joseph Timothy, Johnson, Jr, Theodore O, Tikhe, Jayashree Girish
Format Patent
LanguageEnglish
Published 14.06.2005
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Summary:Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.