Virus-free plasma protein compositions treated with porous membrane and process for producing the same

Contaminant viruses can be efficiently removed almost without losing the activity of protein by subjecting a plasma protein composition having a high risk of viral contamination to a treatment with a porous membrane having a pore size greater than a single-particle size of the virus, particularly by...

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Bibliographic Details
Main Authors Takahashi, Tsuyoshi, Furushima, Koji, Morita, Masanori, Tsujikawa, Muneo, Urayama, Takeru, Hamato, Nobuaki
Format Patent
LanguageEnglish
Published 15.03.2005
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Summary:Contaminant viruses can be efficiently removed almost without losing the activity of protein by subjecting a plasma protein composition having a high risk of viral contamination to a treatment with a porous membrane having a pore size greater than a single-particle size of the virus, particularly by subjecting a plasma protein composition to a fractionation treatment by precipitation, before the porous membrane treatment. Particularly, a fibrinogen composition substantially free of non-enveloped viruses, Parvovirus among others, can be provided. By the application of the present invention, a safe plasma protein preparation free of viruses can be conveniently provided.