Small-molecule inhibitors of interleukin-2

1. Field of the Invention Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune disea...

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Bibliographic Details
Main Authors Arkin, Michelle R, McDowell, Robert S, Oslob, Johan D, Raimundo, Brian C, Waal, Nathan D, Yu, Chul Hyun
Format Patent
LanguageEnglish
Published 19.10.2004
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Summary:1. Field of the Invention Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.