Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation

• Main Authors: Brugnara, Carlo, Halperin, Jose, Fluckiger, Rudolf, Bellott, Jr., Emile M, Lombardy, Richard John, Clifford, John J, Gao, Ying-Duo, Haidar, Reem M, Kelleher, Eugene W, Moussa, Adel M, Sachdeva, Yesh P, Sun, Minghua, Taft, Heather N
• Format: Patent
• Language: English
• Published: 05.10.2004

The present invention relates to aromatic organic compounds which are specific, potent and safe inhibitors of the Ca -activated potassium channel (Gardos channel) of erythrocytes and/or of mammalian cell proliferation. The compounds can be used to reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation in situ as a therapeutic approach towards the treatment or prevention of sickle cell disease. The compounds can also be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation. The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.