Indolopyrrolocarbazole derivatives and antitumor agents

• Main Authors: Kojiri, Katsuhisa, Kondo, Hisao, Arakawa, Hiroharu, Ohkubo, Mitsuru, Suda, Hiroyuki
• Format: Patent
• Language: English
• Published: 09.03.2004

This invention is useful in the pharmaceutical field, and, more detailedly, relates to novel indolopyrrolocarbazole derivatives inhibiting growth of tumor cells and exerting antitumor effect, and their use as antitumor agents. A compound represented by the formula or a pharmaceutically acceptable salt thereof wherein R represents an unsubstituted pyridyl, furyl or thienyl group, or a pyridyl, furyl or thienyl group each of which has one or more substituents selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group except that when the pyridyl, furyl or thienyl group has a lower alkoxy group as a substituent, each of which simultaneously has another substituent selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group, m represents an integer of 1 to 3, and G represents a -D-glucopyranosyl group, and the positions of substitution of the hydroxyl groups on the indolopyrrolocarbazole ring are the 1- and 11-positions, or the 2- and 10-positions, and an antitumore agent containing it as an effective ingredient.The compounds have a better antitumor action than known compounds having a similar structure.