Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same

• Main Authors: Takenouchi, Kazuya, Gao, Qingzhi, Manabe, Kenji, Sogawa, Ryo, Takano, Yasuhiro, Ishizuka, Seiichi
• Format: Patent
• Language: English
• Published: 10.02.2004

The present invention relates to vitamin D derivatives useful as pharmaceutical products or pharmaceutically permissible solvates thereof, treating agents using same and pharmaceutical compositions containing same. More particularly, the invention relates to 1 -hydroxyvitamin D derivatives having neutrophilic infiltration-suppressing activity and antagonistic effect to vitamin D or pharmaceutically permissible solvates thereof, treating agents for inflammatory respiratory diseases and diseases attributable to the overactivity of vitamin D containing same as active ingredients and pharmaceutical compositions containing same. Compounds expressed by the following general formula (1), [wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formula (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.