Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors

This invention relates to a group of biphenyl sulfonamide compounds and derivatives which inhibit matrix metalloproteinase enzymes and thus are useful for treating diseases resulting from connective tissue breakdown, such as heart disease, multiple sclerosis, arthritis, atherosclerosis, and osteopor...

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Bibliographic Details
Main Authors Barvian, Nicole Chantel, O'Brien, Patrick Michael, Patt, William Chester, Sliskovic, Drago Robert
Format Patent
LanguageEnglish
Published 03.02.2004
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Summary:This invention relates to a group of biphenyl sulfonamide compounds and derivatives which inhibit matrix metalloproteinase enzymes and thus are useful for treating diseases resulting from connective tissue breakdown, such as heart disease, multiple sclerosis, arthritis, atherosclerosis, and osteoporosis. Inhibitors of MMP enzymes are cyclic sulfonamides of Formula I or a pharmaceutically acceptable salt thereof, and cyclic sulfonamides of Formula III or a pharmaceutically acceptable salt thereof,wherein Rand Rinclude hydrogen, alkyl, and substituted alkyl; Rand Rinclude hydrogen, halo, and alkyl; X is OH or NHOH: Z is (CH): and Y is S, SO or SO. The compounds of Formulas I and III are useful for the treatment of diseases mediated by an MMP enzyme, including cancer, osteoarthritis, rheumatoid arthritis, heart failure, and inflammation.