Soluble compositions of triphenylethylene antiestrogens

The present invention relates to aqueous solutions of nonsteroidal triphenyl-ethylene antiestrogens for pharmaceutical use and to methods for the preparation thereof. Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agen...

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Bibliographic Details
Main Authors Af Ursin, Kaija, Salmia, Jukka, Niskanen, Heikki, Kortesuo, Pirjo, Kananen, Mikko, Örn, Gunilla, Kiesvaara, Juha
Format Patent
LanguageEnglish
Published 14.10.2003
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Summary:The present invention relates to aqueous solutions of nonsteroidal triphenyl-ethylene antiestrogens for pharmaceutical use and to methods for the preparation thereof. Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1-4 hydroxyl, 1-3 oxo, or one or several halogen a substituents, or a corresponding anion thereof, or methanesulfonic acid or its corresponding anion, in molar excess with respect to the triphenylethylene antiestrogen, optionally together with an organic water miscible co-solvent such as polyethylene glycol (PEG), propylene glycol, ethanol or isopropanol.