Dibenzo[c]chromen-6-one derivatives as anti-cancer agents

• Main Authors: Schmidt, Jonathan Martin, Redden, Peter, Mercure, Julie, Zhu, Shuguang, Whelan, John, Lazarowych, Natalie
• Format: Patent
• Language: English
• Published: 14.10.2003

The present invention relates to a series of new chemical agents that demonstrate anti-proliferative effects against human endothelial cells for the treatment of a variety of diseases including cancer, in addition to an inhibitory effect directly on cancer cells for the treatment of solid tumors. More particularly, the present invention relates to molecules that demonstrate anti-proliferative capabilities against human endothelial cells and several epithelial cancer cells and their applications in treating a variety of disease states. Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo[b,d]pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.