Taxane synthesis method and intermediates

The present invention is directed to a process for the preparation of baccatin III, taxol, docetaxel and their analogs from borneol (1) and camphor (2), commonly known articles of commerce. A process for the preparation of a composition having the formula: in which a compound having the formula: is...

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Bibliographic Details
Main Authors Holton, Robert A, Vu, Phong, Gharbaoui, Tawfik, Reboul, Vincent
Format Patent
LanguageEnglish
Published 07.10.2003
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Summary:The present invention is directed to a process for the preparation of baccatin III, taxol, docetaxel and their analogs from borneol (1) and camphor (2), commonly known articles of commerce. A process for the preparation of a composition having the formula: in which a compound having the formula: is treated with a base and a silylating agent.