Indole derivatives and their use as MCP-1 receptor antagonists

The present invention relates to chemical compounds, to their production as well as to pharmaceutical compositions containing them as well as to their use in therapy, in particular of inflammatory disease. The present invention relates to certain novel compounds, including their production, their fo...

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Bibliographic Details
Main Authors Kettle, Jason, Faull, Alan W
Format Patent
LanguageEnglish
Published 02.09.2003
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Summary:The present invention relates to chemical compounds, to their production as well as to pharmaceutical compositions containing them as well as to their use in therapy, in particular of inflammatory disease. The present invention relates to certain novel compounds, including their production, their formulation as pharmaceutical compositions, and their therapeutic uses. In particular, the invention discloses certain indole derivatives and their function as inhibitors of monocyte chemoattractant protein-1 (MCP-1) and RANTES induced chemotaxis. The invention also discloses the use of the novel compounds in the treatment of inflammatory disease.