PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5′-ETHOXY-4-CIS[2-(4-MORPHOLINO)ETHOXY]-2′-OXOSPIRO[CYCLOHEXAN-1,3′[H]INDOL]1′(2′-H)-YL]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS

The subject of the present invention is a process for the preparation of N-(1,1-dimethylethyl)-4-[[5′-ethoxy-4-cis-[2-(4-morpholino)ethoxy]-2′-oxospiro[cyclohexan- 1,3′-[3H]indol]-1′(2′H)-yl]-sulfonyl]-3-methoxybenzamide (SR 121463) of formula I The invention relates to a process for the preparation...

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Main Authors Héja, Gergely, Csikós, Éva, Takácsy, Tünde Erösné, Gönczi, Csaba, Halász, Judit, Hermecz, István, Majláth, Csilla, Nagy, Lajos, Csutor, Andrea Sántáné, Sárosi, Péter, Simon, Kálmán, Szomor, Tiborné, Szvoboda, Györgyné
Format Patent
LanguageEnglish
Published 29.07.2003
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Summary:The subject of the present invention is a process for the preparation of N-(1,1-dimethylethyl)-4-[[5′-ethoxy-4-cis-[2-(4-morpholino)ethoxy]-2′-oxospiro[cyclohexan- 1,3′-[3H]indol]-1′(2′H)-yl]-sulfonyl]-3-methoxybenzamide (SR 121463) of formula I The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reaction in dimethyl sulfoxide, at a temperature between 10° C. and 40° C., preferably at room temperature and transforming the resulting base of formula (I), if desired, into its salt by a method known per se.