Immunoassay for 2-oxo-3-hydroxy LSD

This invention relates generally to the field of the detection of drugs and drug metabolites in biological samples. Specifically, the invention relates to the generation of antibodies that specifically bind to a metabolite of LSD, 2-oxo-3-hydroxy-LSD, or those that recognize both the metabolite and...

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Bibliographic Details
Main Authors Sanchez, Anthony de Jesus, Davoudzadeh, David, Coty, William A
Format Patent
LanguageEnglish
Published 15.04.2003
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Summary:This invention relates generally to the field of the detection of drugs and drug metabolites in biological samples. Specifically, the invention relates to the generation of antibodies that specifically bind to a metabolite of LSD, 2-oxo-3-hydroxy-LSD, or those that recognize both the metabolite and the parent drug LSD. The compositions and methods of the present invention are particularly useful for confirming the presence of LSD or LSD metabolites in a sample potentially containing interfering substances. To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an immunoassay reagent in which the 2-oxo-3-hydroxy-LSD is conjugated in the same position to a labeling or separation means. The set of reagents can be used in immunoassays for detecting or confirming the presence of LSD or LSD metabolites in a sample potentially containing interfering substances.