Sulfoxide compounds and acetone complexes, and a process for producing the same

• Main Authors: Tsujii, Masahiko, Niikawa, Nobuo, Takayanagi, Keizo, Nochi, Shigeharu
• Format: Patent
• Language: English
• Published: 08.04.2003

The present invention relates to a novel acetone complex of a sulfoxide compound or of a pharmacologically acceptable salt thereof useful as medicines such as inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines, as described in JP-A 1-6270 (Example 32), JP-A 61-50978 (Example 2), JP-A 54-141783 (Example 21) or JP-A 61-22079 (Example 2), a process for producing the same and a purification method using the same. The present invention provides acetone complexes of sulfoxide compounds, useful as medicines such as inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines, a process for producing the same and a purification method of using the same.Namely, it is the acetone complexes of sulfoxide compounds or of pharmaceutically acceptable salts thereof represented by the following formula: (wherein Rrepresents a hydrogen atom, a methoxy group or a difluoromethoxy group, Rrepresents a methyl group or a methoxy group, Rrepresents a 3-methoxypropoxy group, a methoxy group or a 2,2,2-trifluoroethoxy group, Rrepresents a hydrogen atom or a methyl group, n and m independently represent an integer of 1 to 4, and B represents a hydrogen atom, an alkali metal atom or ½ alkaline earth metal atom), which are obtained by treating the sulfoxide compounds or pharmaceutically acceptable salts thereof with acetone.