Process for the preparation of spiro[cis-4-( -hydroxyethyloxy)cyclohexane-[3h]indol]-2′[1′H]one derivatives

This application is a 371 of PCT/HU00/00079 filed Jul. 13, 2000. The invention relates to a process for the preparation of spiro[cis-4-( -hydroxyethyloxy)cyclohexane-[3H]indol]-2′[1′H]-one derivatives of the formula (I) wherein Rand Rare as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2...

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Main Authors Héja, Gergely, Csikós, Éva, Gönczi, Csaba, Halász, Judit, Hajdú, Félix, Hermecz, István, Kis, László, Nagy, Lajos, Csutor, Andrea Sántáné, Simon, Kálmán, Szomor, Tiborné, Szvoboda, Györgyné
Format Patent
LanguageEnglish
Published 01.04.2003
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Summary:This application is a 371 of PCT/HU00/00079 filed Jul. 13, 2000. The invention relates to a process for the preparation of spiro[cis-4-( -hydroxyethyloxy)cyclohexane-[3H]indol]-2′[1′H]-one derivatives of the formula (I) wherein Rand Rare as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4′-cyclohexane-1′3′-[3H]indol]-2″[1″H]-one derivative of general formula (II), wherein Rand Rare as defined herein, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.