Substituted oxazoles and thiazoles derivatives as hPPAR and hPPAR activators

The present invention relates to certain novel compounds, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. More particularly, it relates to compounds which exhibit activation, including dual agonist activity, to peroxisome proliferator-...

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Bibliographic Details
Main Authors Collins, Jon Loren, Dezube, Milana, Oplinger, Jeffrey Alan, Willson, Timothy Mark
Format Patent
LanguageEnglish
Published 24.12.2002
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Summary:The present invention relates to certain novel compounds, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. More particularly, it relates to compounds which exhibit activation, including dual agonist activity, to peroxisome proliferator-activated receptors gamma (PPAR ) and alpha (PPAR ) thereby enabling them to modulate the blood glucose and lipid levels in mammals. The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual activators of hPPAR and hPPAR{acute over ( )}.