DNA vaccine for protecting an avian against infectious bursal disease virus
This invention provides a vaccine for protecting an avian against an avian pathogen such as Infectious Bursal Disease Virus, Newcastle Disease Virus, or Mycoplasma gallisepticum, which comprises an effective immunizing amount of a vector comprising an isolated nucleic acid encoding Infectious Bursal...
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Format | Patent |
Language | English |
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22.10.2002
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Abstract | This invention provides a vaccine for protecting an avian against an avian pathogen such as Infectious Bursal Disease Virus, Newcastle Disease Virus, or Mycoplasma gallisepticum, which comprises an effective immunizing amount of a vector comprising an isolated nucleic acid encoding Infectious Bursal Disease Virus peptides such as VP1, VP1s1, VP1s2, VP2, VP2S, VP3, VP4, VP4S and VP5, and a suitable carrier. Further, this invention provides a method for enhancing an avian immune response which comprises administering to the avian an effective amount of the vaccine and a method of immunizing an avian comprising administrating to the avian an effective amount of the vaccine.
This invention provides a vaccine for protecting an avian species against infectious bursal disease virus which comprises an effective immunizing amount of a vector comprising 1) one or more isolated nucleic acids encoding an infectious bursal disease virus polypeptide; and 2) a suitable carrier and/or adjuvant. |
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AbstractList | This invention provides a vaccine for protecting an avian against an avian pathogen such as Infectious Bursal Disease Virus, Newcastle Disease Virus, or Mycoplasma gallisepticum, which comprises an effective immunizing amount of a vector comprising an isolated nucleic acid encoding Infectious Bursal Disease Virus peptides such as VP1, VP1s1, VP1s2, VP2, VP2S, VP3, VP4, VP4S and VP5, and a suitable carrier. Further, this invention provides a method for enhancing an avian immune response which comprises administering to the avian an effective amount of the vaccine and a method of immunizing an avian comprising administrating to the avian an effective amount of the vaccine.
This invention provides a vaccine for protecting an avian species against infectious bursal disease virus which comprises an effective immunizing amount of a vector comprising 1) one or more isolated nucleic acids encoding an infectious bursal disease virus polypeptide; and 2) a suitable carrier and/or adjuvant. |
Author | Monadeev, Limor Pirak, Michael E Shaoul, Esther Aboud-Pirak, Esther |
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References | Felgner et al. (5580859) 19961200 (WO 98/09646) 19980300 Iwasaki, A. et al., "Enhanced CTL Responses Mediated by Plasmid DNA Immunogens Encoding Costimulatory Molecules and Cytokines." 1997, Journal of Immunology, vol. 158, pp. 4591-4601. Smith and Waterman, Adv. App. Math., 1981, 2:482-489. Pearson and Lipman, Proc. Natl. Acad. Sci (USA), 1988, 85:2444-2448. Azad et al., Virology, 1987, pp. 145-153. Davis, H. L. et al., "Direct gene transfer in skeletal muscle:plasmid DNA-based immunization against the hepatitisB virus surface antigen." 1994, Vaccine, vol. 12, pp. 1503-1509. Macreadie and Azad, Vaccine Science, 1990, pp. 549-552. (WO 98/03659) 19980100 Sanger et al., Proc Natl. Acad. Sci. 74, 1977, pp 5463-5467. Azad et al. (5614409) 19970300 Jackwood et al. (5605792) 19970200 Vakharia et al. (5788970) 19980800 (WO 9116925) 19911100 Kodihalli et al., J. Virol., vol. 71, 1997, pp. 3391-3396. (WO 8810298) 19881200 W. French Anderson, "Human gene therapy" 1998, Nature, vol. 392, pp. 25-30. Robinson et al., Vaccine vol. 1, 1993, pp. 957-960. Jackwood et al. (5605827) 19970200 Laemmli, Nature, London, 1970, 227, 680-685. Audonnet et al. (5733554) 19980300 Vakharia et al., Vaccine 2, 452-456, 1994. Paoletti et al. (5641490) 19970600 Azad et al. (5350575) 19940900 Lanzavecchia, A. "Identifying Strategies for Immune Intervention." 1993, Science, vol. 260, pp. 937-944. Needleman and Wunsch, J. Mol. Biol., 1970, 48:443-453. Snyder et al. (5518724) 19960500 Bayliss et al. "A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus," Arch. Virol. 1991, vol. 120, pp. 193-205, especially abstract, p. 193. Chamczynski and Scchi, Anal. Biochem., 1987, 162:156-159. Vakharia et al. (5595912) 19970100 Maruta et al. (5610047) 19970300 Towbin et al., Proc. Natl. Acad. Sci. (USA), 76, 1979, p. 4350-4354. Felgner et al. (5589466) 19961200 Pitcovski et al., Avian Diseases 40, 1996, 753-761. Snyder et al. (5632989) 19970500 Wolff et al. (5693622) 19971200 |
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