Methods of administering adenoviral vectors

The present invention relates to methods useful in the administration of gene products to animals using adenoviral vectors. The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic ne...

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Bibliographic Details
Main Authors Bruder, Joseph T, Kovesdi, Imre
Format Patent
LanguageEnglish
Published 27.08.2002
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Summary:The present invention relates to methods useful in the administration of gene products to animals using adenoviral vectors. The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies to neutralize the adenoviral gene transfer vector outside a targeted muscle. Another method involves the repeat administration of an adenoviral gene transfer vector to a skeletal muscle.