Pyrimidine-5-carboxamide derivatives

This invention relates to medicaments, particularly pyrimidine-5-carboxamide derivatives having Syk tyrosine kinase inhibition activity. Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning;X: O, S, NR, CO, NRCO, CO...

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Main Authors Hisamichi, Hiroyuki, Naito, Ryo, Kawazoe, Souichirou, Toyoshima, Akira, Tanabe, Kazuhito, Nakai, Eiichi, Ichikawa, Atsushi, Orita, Akiko, Takeuchi, Makoto
Format Patent
LanguageEnglish
Published 13.08.2002
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Summary:This invention relates to medicaments, particularly pyrimidine-5-carboxamide derivatives having Syk tyrosine kinase inhibition activity. Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning;X: O, S, NR, CO, NRCO, CONR, C N-ORor a bond,Y: a lower alkylene group which may be substituted by ORor -NHR, or a bond,Z: O, NRor a bond,A: H, or a lower alkyl which may have a substituent, a -CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent,B: an aryl which may have a substituent or a heteroaryl group which may have a substituent,R, R: H, a lower alkyl or a -CO-lower alkyl group].