Tocopherol derivatives and method for preparation thereof

• Main Authors: Kim, Kil Joong, Kim, Duck Hee, Rho, Ho Sik, You, Jae Won, Nam, Chun Ja, Hong, Jong Eoun, Kang, Hak Hee, Chang, Ih Seob
• Format: Patent
• Language: English
• Published: 25.06.2002

1. Field of the Invention An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: Wherein,R, Rand Rare H or methyl group, and at least one positions selected from group consisting of the R, Rand Rpositions are methyl group; and,A is CH-CH(CH)- or CH C(CH)-The other object of the present invention is to provide a method for preparing the above tocopherol derivatives. The tocopherol derivatives is prepared by reacting tocopherol with phosphorous oxychloride in an equivalent ratio of 1:1˜1.3, in presence of an organic base, in an organic solvent; reacting the tocopherol dichlorophosphate produced by the above reaction with 3-aminopropanol in presence of an organic base, in an organic solvent; and, hydrolyzing the above products.The tocopherol derivatives according to the present invention can be hydrolyzed by biological enzymes in a living body to produce tocopherol and 3-aminopropane phosphate. And they can induce physiological activities including recovery of injured skin, prevention from aging of bio-membrane, etc. Also, the tocopherol derivatives according to the present invention have improved stability, safety to skin and anti-oxidant effect superior to preceding tocopherol and its derivatives.