Composition and method for decreasing neurologic symptomatology

• Main Author: Swope, David M
• Format: Patent
• Language: English
• Published: 30.04.2002

Parkinson's Disease is a chronic, progressive, neurodegenerative disease of unknown cause. It is characterized by tremor, rigidity, slowness of movement and loss of postural reflexes. Disability from Parkinson's Disease results from the progressive impairment of mobility, as well as a form of dementia that often accompanies the disease. A method of decreasing the signs or symptomatology in a patient with a neurologic condition or disease, or in a patient due to effects of exposure to an exogenous substance, such as a pharmaceutical agent, comprising selecting a patient having at least one sign or symptom selected from the group consisting of akinesia, bradykinesia, dyskinesias, gait disturbances, posture disturbances, rigid limbs, speech impairments and tremor and administering to the patient one or more than one effective doses of a phosphodiesterase inhibitor. A composition for decreasing the signs or symptomatology in a patient with a neurologic condition or disease, or in a patient due to effects of exposure to an exogenous substance, such as a pharmaceutical agent, the composition comprising an effective dose of one or more than one phosphodiesterase inhibitor combined with an effective dose of one or more than one additional pharmaceutical agent known to decrease signs or symptomatology in a patient with a neurologic condition or disease.