sheet mimetics and methods relating to the use thereof

This invention relates generally to -sheet mimetics and, more specifically, to -sheet mimetics which inhibit biologically active peptides and proteins. -sheet mimetics and methods relating to the same are disclosed. The -sheet mimetics have utility as protease and kinase inhibitors, as well as inhib...

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Bibliographic Details
Main Authors Qabar, Maher N, McMillan, Michael K, Kahn, Michael S, Tulinsky, John E, Ogbu, Cyprian O, Mathew, Jessymol
Format Patent
LanguageEnglish
Published 16.04.2002
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Summary:This invention relates generally to -sheet mimetics and, more specifically, to -sheet mimetics which inhibit biologically active peptides and proteins. -sheet mimetics and methods relating to the same are disclosed. The -sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a -sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.