Mammalian growth factor

This invention is related to a novel polypeptide having mammalian growth factor activity and to methods for using it. A homogeneous K-FGF polypeptide having a molecular weight of about 19,000 daltons when analyzed by SDS polyacrylamide gel electrophoresis, wherein the polypeptide is substantially fr...

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Bibliographic Details
Main Authors Basilico, Claudio, Delli Bovi, Pasquale
Format Patent
LanguageEnglish
Published 12.03.2002
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Summary:This invention is related to a novel polypeptide having mammalian growth factor activity and to methods for using it. A homogeneous K-FGF polypeptide having a molecular weight of about 19,000 daltons when analyzed by SDS polyacrylamide gel electrophoresis, wherein the polypeptide is substantially free of oligosaccharide moieties attached to the polypeptide, appears as a single band on SDS-PAGE, exhibits a detectable level of mitogenic activity on growth arrested cells in a H-thymidine uptake assay, and is substantially free from other mammalian proteins, is provided.