Asymmetric conjugate addition reaction

The present invention relates to novel key intermediates in the synthesis of an endothelin antagonist and the method for preparing these key intermediates of Formula I. This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate vi...

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Bibliographic Details
Main Authors Devine, Paul N, Tillyer, Richard D, Heid, Jr., Richard M, Tschaen, David M
Format Patent
LanguageEnglish
Published 05.03.2002
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Summary:The present invention relates to novel key intermediates in the synthesis of an endothelin antagonist and the method for preparing these key intermediates of Formula I. This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.