Detection of variations in human H2 receptors

• Main Authors: Wright, Simon, Heath, Paul, Orange, Paul, Pearson, Ronald Carl Alan
• Format: Patent
• Language: English
• Published: 12.02.2002

This invention relates to the detection of variations in human histamine H receptors, and more particularly to the development of new compounds useful in the sequencing and identification of a human histamine H receptor and their use in the diagnosis and treatment of certain human disorders, for example, brain disorders. The invention also relates to new compounds and a method for detecting an allelic polymorphic variation within the human population for the gene encoding the histamine H receptor, and their use in the diagnosis and treatment of human disorders. A group of oligonucleotides for the identification of sequences in a sample comprising human histamine Hreceptor DNA, cDNA or RNA originating from a tissue sample or body fluid is employed in the diagnosis and/or treatment of human neurological and psychiatric disorders, particularly schizophrenia, and diseases of other systems or organs of the human body. The oligonucleotides, suitable for use as primers for the amplification of DNA corresponding to a region of a human histamine Hreceptor, have nucleotide sequences selected from: 5′ACACCAGCCTGGATGTGA 3′(as listed in SEQ ID NO:12), 5′TCACATCCAGGCTGGTCT 3′ (as listed in SEQ ID NO:13), 5′ CAATCATACCACCTCTAA 3′ (as listed in SEQ ID NO:14), 5′ ACACAAACGCGGTGAAGT 3′(as listed in SEQ ID NO:15). Also described is a diagnostic kit comprising one or more of the above mentioned oligonucleotides.