Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of the healthy-skin

• Main Authors: Schreiner, Volker, Sauermann, Gerhard, Doring, Thomas, Siefken, Wilfried, Gatermann, Cornelia, Carstensen, Stefanie, Biergiesser, Helga, Blatt, Thomas
• Format: Patent
• Language: English
• Published: 23.12.2004

The invention relates to the use of preparations to be applied topically having a content of a) one or more compounds from the group formed by creatine and precursors and derivatives thereof, b) optionally one or more compounds from the group of electrolytes, c) optionally one or more compounds from the group of polyols and urea and optionally d) one or more compounds from the group of osmolytes, for the treatment and active prevention of dry skin and for strengthening the barrier function of the skin, and for the treatment, care and prophylaxis of sensitive skin and/or for the treatment and prophylaxis of the symptoms of a negative change in the physiological homeostasis of healthy skin, in particular deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive conditions of skin appendages, inflamed skin conditions, and of atopic eczema, polymorphous photodermatosis, psoriasis, vitiligo, sensitive, itching or irritated skin, changes in normal lipid peroxidation, a change in the ceramide, lipid and energy metabolism of healthy skin, a change in the physiological transepidermal water loss, a reduction in skin hydration and decrease in the moisture content of the skin, change in the natural moisturizing factor content, reduction in cell-cell communication, deficiency symptoms of intracellular DNA synthesis, DNA damage and reduction in endogenous DNA repair mechanisms, activation of metalloproteinases and/or other proteases or inhibition of the corresponding endogenous DNA repair mechanisms, deviations from the normal post-translational modifications of connective tissue constituents, changes in the normal hyaluronic acid and glucosaminoglycan content of healthy skin, dandruff formation by the hair, flaking of the scalp and skin ageing.