Process for producing hydroxyamino acid derivative

Provided is a method of preparing a hydroxyamino acid derivative, particularly in an optically active form thereof with high efficiency. Specifically, provided is a method of preparing hydroxyamino acid derivatives represented by Formula (I) or salts thereof: 1 , characterized in that an amino acid...

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Bibliographic Details
Main Authors Matsumoto, Naoki, Kaneko, Katsura, Nagai, Hazuki, Konuki, Kaname, Tsuchida, Toshio, Issiki, Kunio
Format Patent
LanguageEnglish
Published 09.12.2004
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Summary:Provided is a method of preparing a hydroxyamino acid derivative, particularly in an optically active form thereof with high efficiency. Specifically, provided is a method of preparing hydroxyamino acid derivatives represented by Formula (I) or salts thereof: 1 , characterized in that an amino acid derivative represented by Formula (II): 2 is subjected to a selective reduction reaction of a carboxyl group at a side chain terminus in a solvent, and then, optionally, subjected to an elimination reaction of a protecting group of an amino group or a salt-formation reaction of an amino group or a carboxyl group.