Salts of tricyclic inhibitors of poly(ADP-ribose) polymerases

Pharmaceutically acceptable salts of compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compou...

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Main Authors Canan-Koch, Stacie, Chu, Jan-Jon, Liu, Jia, Matthews, Jean
Format Patent
LanguageEnglish
Published 09.12.2004
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Summary:Pharmaceutically acceptable salts of compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.