Crystalline forms of ertapenem sodium

• Main Authors: Brands, Karel, Cvetovich, Raymond, Crocker, Louis, Ward, Michael, Mahajan, Amar, Wenslow, Robert, Williams, John, Sidler, Daniel, Orella, Charles, Fisher, Elizabeth
• Format: Patent
• Language: English
• Published: 25.11.2004

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1 characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution contain...