Crystalline forms of ertapenem sodium

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1 characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution contain...

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Main Authors Brands, Karel, Cvetovich, Raymond, Crocker, Louis, Ward, Michael, Mahajan, Amar, Wenslow, Robert, Williams, John, Sidler, Daniel, Orella, Charles, Fisher, Elizabeth
Format Patent
LanguageEnglish
Published 25.11.2004
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Summary:A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1 characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C 2-5 alcohol at between −5 and −25° C.